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TCO-PEG4-NHS ester
CAS No. 1613439-69-2
TCO-PEG4-NHS ester( —— )
Catalog No. M33513 CAS No. 1613439-69-2
TCO-PEG4-NHS ester is a PROTAC linker bridge in the PEG class, used for synthesizing various PROTAC molecules.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 181 | In Stock |
|
| 50MG | 288 | In Stock |
|
| 100MG | 444 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTCO-PEG4-NHS ester
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NoteResearch use only, not for human use.
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Brief DescriptionTCO-PEG4-NHS ester is a PROTAC linker bridge in the PEG class, used for synthesizing various PROTAC molecules.
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DescriptionTCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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In Vivo——
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Synonyms——
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PathwayAntibody Drug Conjugates (ADC)
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TargetADCs Linker/Click Chemistry
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RecptorADC Linker | PROTACs
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Research Area——
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Indication——
Chemical Information
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CAS Number1613439-69-2
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Formula Weight514.57
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Molecular FormulaC24H38N2O10
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (97.17 mM; Ultrasonic )
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SMILESO(C(CCOCCOCCOCCOCCNC(OC1CCCC=CCC1)=O)=O)N2C(=O)CCC2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jung S, et al. An integrated approach for enhanced protein conjugation and capture with viral nanotemplatesand hydrogel microparticle platforms via rapid bioorthogonal reactions. Langmuir. 2014 Jul 8;30(26):7762-70.?
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DBCO-NHS ester
An amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine.
